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Scientist, Biologics Development

Research & Development
185297 Requisition #
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Allergan plc (NYSE: AGN) is a bold, global pharmaceutical company and a leader in a new industry model - Growth Pharma. Allergan is focused on developing, manufacturing and commercializing branded pharmaceutical, device, biologic, surgical and regenerative medicine products for patients around the world.

Allergan markets a portfolio of leading brands and best-in-class products for the central nervous system, eye care, medical aesthetics and dermatology, gastroenterology, women's health, urology and anti-infective therapeutic categories. With commercial operations in approximately 100 countries, Allergan is committed to working with physicians, healthcare providers and patients to deliver innovative and meaningful treatments that help people around the world live longer, healthier lives every day. 

Allergan is a company that will inspire you to aim high with your ambition. Where you can build bridges all over the world. Where you can power ideas that drive change. And where you will act fast and drive results for customers and patients.  Power your future & join our bold team. 

Position Overview

The Scientist, purification will be an instrumental team member of the Biologics Development Process Sciences Department, based in Irvine, CA.  The primary role of the scientist, purification is to execute of all aspects of purification process development, process scale up and GMP manufacturing support. Particularly, the position is responsible for independently plan, design, and executes the experiments and develops processes to support the purification of natural and recombinant proteins (including neurotoxin and antibodies) from bacterial as well as mammalian cell cultures at small and intermediate scale during various stages of development.
The scientist in this position is expected to possess a clear understanding and in-depth knowledge and experience including but not limited to: chromatography processes, ultrafiltration/diafiltration, process characterization and optimization, process scale up, scale down model qualifications and validation. The ability to demonstrate a significant level of hands on experience in several of these areas is expected. Additional responsibilities include data analysis, troubleshooting process and equipment, participation in project teams, lab inventory and organization, maintaining detailed records of batches and experiments.
This position also requires a desire and ability to work as an integral part of a team and supporting drug discovery teams as well as demonstrate a high degree of flexibility, creativity, and initiative applied to the various duties and aspects of position.
Furthermore, the position requires the individual to work with and in areas requiring select agents and Toxins access (i.e. Biosafety level 2 and biosafety level 3 laboratories). Access to and use of select agents is regulated by federal policies. Therefore, the candidate must conduct all work activities in compliance with Allergan internal and applicable regulatory requirements.  Allergan internal requirements include compliance with ethics, environmental health and safety, financial, human resources, and general business policies, requirements and objectives.  

Areas of Responsibilities

  • Hands on laboratory bench work to develop and prepare biologics products candidates for various groups with tight timelines.
  • Independently operate and have sound knowledge of AKTA pure and AKTA Ready chromatography systems. Position requires proficient knowledge and hands on experience of clarification equipment as well.
  • Routine down-stream purification operations relating to AKTA chromatography system prep: assembly/disassembly, in process sampling and media/buffer/reagent prep and able to troubleshoot operational and equipment issues.
  • Must be willing to work with and handle potent neurotoxins and in-process samples that contain neurotoxin and neurotoxin expressing organisms. Ability to perform all operation and manipulation under a biosafety laminar flow hood.
  • Follow study protocols and execute experiments independently (or minimal supervision) at small scales and large scale
  • Demonstrate technical competence in executing purification experiments utilizing detailed knowledge of standard analytical techniques in purification process development and data analysis.
  • Author and edit development batch records and associated standard operating procedures. Compile experimental batch records and documents/inventory for in-process samples in the inventory system.
  • Additional responsibilities are lab inventory and organization. Individual will evaluate lab equipment and procure the necessary supplies to ensure continual successful lab operations.
  • Assist purification team in tech transfer for process developed at small scale to early stage process development laboratory (internally or externally).
  • The scientist must complete training consistent with safety, technical, operational, process, and other skill/ knowledge requirements for the position. Maintain all training to current status. Support safety program and ensure safety in all routine and new operations by strictly following SOPs.


The following listed requirements need to be met at a minimum level to be considered for the job:

  • Hands-on experience in the operation of purification AKTA chromatography system is required.
  • Must have extended knowledge of chemical principles applicable to protein purification
  • Must work in a team setting with other members of the group and prioritize and allocate time and effort appropriately
  • Must demonstrate success in technical proficiency, scientific creativity, collaboration with others and independent thought
  • Must be self-motivated to develop and evaluate hypotheses as they pertain to protein purification and the resulting scale up of purification processes


  • PhD in Biological Science, Biochemistry, Protein Chemistry, Biochemical/Chemical Engineering or a related Life Science field with 0-2 years of relevant industrial experience or MS with 2+ years or BS with 4+ years of related work experience.

Equal Employment Opportunity Employer

Allergan is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other protected status.

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